Construction of a support tool for the design of the activity structures based computer system architectures

This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.This thesis is a reapproachment of diverse design concepts, brought to bear upon the computer system engineering problem of identification and control of highly constrained multiprocessing (HCM) computer machines. It contributes to the area of meta/general systems methodology, and brings a new insight into the design formalisms, and results afforded by bringing together various design concepts that can be used for the construction of highly constrained computer system architectures. A unique point of view is taken by assuming the process of identification and control of HCM computer systems to be the process generated by the Activity Structures Methodology (ASM). The research in ASM has emerged from the Neuroscience research, aiming at providing the techniques for combining the diverse knowledge sources that capture the 'deep knowledge' of this application field in an effective formal and computer representable form. To apply the ASM design guidelines in the realm of the distributed computer system design, we provide new design definitions for the identification and control of such machines in terms of realisations. These realisation definitions characterise the various classes of the identification and control problem. The classes covered consist of: 1. the identification of the designer activities, 2. the identification and control of the machine's distributed structures of behaviour, 3. the identification and control of the conversational environment activities (i.e. the randomised/ adaptive activities and interactions of both the user and the machine environments), 4. the identification and control of the substrata needed for the realisation of the machine, and 5. the identification of the admissible design data, both user-oriented and machineoriented, that can force the conversational environment to act in a self-regulating manner. All extent results are considered in this context, allowing the development of both necessary conditions for machine identification in terms of their distributed behaviours as well as the substrata structures of the unknown machine and sufficient conditions in terms of experiments on the unknown machine to achieve the self-regulation behaviour. We provide a detailed description of the design and implementation of the support software tool which can be used for aiding the process of constructing effective, HCM computer systems, based on various classes of identification and control. The design data of a highly constrained system, the NUKE, are used to verify the tool logic as well as the various identification and control procedures. Possible extensions as well as future work implied by the results are considered.Government of Ira

A comparison of some performance evaluation techniques

In this thesis we look at three approaches to modelling interactive computer systems: Simulation, Operational analysis and Performance-Oriented design. The simulation approach, presented first, is applied to a general purpose, multiprogrammed, machine independent, virtual memory computer system. The model is used to study the effects of different performance parameters upon important performance indices. It is also used to compare or validate the results produced by the other two methods. The major drawback of the simulation model (i.e. its relatively high cost) has been overcome by combining regression techniques with simulation, using simple experimental case studies. Next, operational analysis was reviewed in a hierarchical way (starting by analysing a single-resource queue and ending up by analysing a multi-class customer general interactive system), to study the performance model of general interactive systems. The results of the model were compared with the performance indices produced using the simulation results. The performance-oriented design technique was the third method used for building system performance models. Here, several optimization design problems have been reviewed to minimize the response time or maximize the system throughput subject to a cost constraint. Again, the model results were compared with the simulation results using different cost constraints. We suggest finally, that the above methods should be used together to assist the designer in building computer performance models

The correlation between atrophic gastritis and Helicobacter pylori infection in patients referred to Shohadaye Ashayer Hospital in Khorramabad

Background: Helicobacter pylori and atrophic gastritis are both known as risk factors for gastric cancer. The purpose of this study is to investigate the prevalence of Helicobacter pylori infection in patients with atrophic gastritis. In addition to being aware of the prevalence of this infection, it is crucial to eliminated of this bacterium due to its carcinogenicity.Methods: In this descriptive-cross-sectional study, all patients referred to the endoscopy unit of Shohadaye Ashayer Hospital in Khorramabad city for endoscopy during 2015–2016 were included. Referees with atrophic gastritis were classified as patients, while those without the condition were classified as the control group. Then, the frequency of H. pylori infection in patients with atrophic gastritis and people without atrophic gastritis was investigated. After sample collection, the primary data was entered into the SPSS software version 22 for analysis.Result: The collected results showed that 2121 patients (41%) did not have H. pylori and 3053 patients (59%) had H. pylori. The population over 50 years old had the highest age frequency in the study subjects, while the female group had the highest gender frequency. As a result, the frequency of H. pylori in the antrum area was higher than in other locations in both endoscopy and pathology, but it was not statistically significant (P value >0.05). 54.1% of those who had endoscopy-discovered atrophy also had severe atrophy. H. pylori was found in the antrum in 50% of cases, and in 61.1% of cases when the pathology showed atrophy. This finding was statistically significant (P value <0.05).The incidence of reporting atrophy was 2.8 times higher in the age group of over 50 compared to those under 20. H. pylori was detected in 56.4% of people over 50 who had atrophy; that was statistically significant.Conclusion: According to the results, there is a significant risk of developing atrophic gastritis in patients with H. pylori, and among females, those over 50 years old have the highest frequency of occurrence

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% 47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% 32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% 27.9-42.8] and 33.3% 25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license